YIGSR-Lys (N3)

YIGSR-Lys (N3) is a peptide that can inhibit the tumour growth and metastasis of leukaemic cells. YIGSR blocks the cellular binding to laminin I via a 67-kDa laminin-binding protein, and inhibits shear-induced increase in eNOS expression of laminin cells[1][2]. YIGSR-Lys (N3) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

2415188-59-7

12352209

NO Synthase

Immunology/Inflammation

Cancer

OC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](N)CC1=CC=C(O)C=C1)=O)[C@H](CC)C)=O)=O)CO)=O)CCCNC(N)=N)=O)CCCCN=[N+]=[N-])=O

C32H52N12O9

748.83

[1]N Yoshida, et al. The laminin-derived peptide YIGSR (Tyr–Ile–Gly–Ser–Arg) inhibits human pre-B leukaemic cell growth and dissemination to organs in SCID mice. Br J Cancer. 1999 Aug; 80 (12) : 1898–1904.|[2]Gloe T, et al. The 67-kDa laminin-binding protein is involved in shear stress-dependent endothelial nitric-oxide synthase expression. J Biol Chem. 1999 Jun 4;274 (23) :15996-6002.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P0132A/

Peptides

No Development Reported