YM-17E (hydrochloride)

YM17E hydrochloride is an acyl CoA:cholesterol acyltransferase (ACAT) inhibitor, with IC50 of 44 nM. YM17E hydrochloride has hypocholesterolemic effect[1][2].

124884-99-7

12352005

Acyltransferase

Metabolic Enzyme/Protease

Metabolic Disease

O=C(NC1=CC=C(N(C)C)C=C1)N(CC2=CC=CC(CN(C3CCCCCC3)C(NC4=CC=C(N(C)C)C=C4)=O)=C2)C5CCCCCC5.Cl.Cl

C40H58Cl2N6O2

725.83

[1]Uchida T, et al. Relationship between bioavailability and hypocholesterolemic activity of YM17E, an inhibitor of ACAT, in cholesterol-fed rats. Atherosclerosis. 1998 Mar;137 (1) :97-106. |[2]Kashiwa M, et al. Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol. 1997 Jan;73 (1) :41-50.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19140/

Reference compound1

Phase 1