YVPGP

YVPGP is an oligopeptide exacted from Anthopleura anjunae. YVPGP has a significant antitumor activity by mediating PI3K/AKT/mTOR signaling pathway. YVPGP arrests DU-145 cells in the S phase and induces apoptosis via mitochondrial and death receptor pathways (caspase3, 7, 8, 9) . YVPGP effectively inhibits tumor growth in DU-145 xenografts mice model, promising for prostate cancer research[1].

2095286-57-8

12352209

Akt; Apoptosis; Bcl-2 Family; Caspase; mTOR; PI3K

Apoptosis; PI3K/Akt/mTOR

Cancer-Kinase/protease

Cancer

O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(NCC(N2[C@@H](CCC2)C(O)=O)=O)=O)=O)[C@H](CC3=CC=C(C=C3)O)N

C26H37N5O7

531.60

[1]Li X, et al. Inhibition of Prostate Cancer DU-145 Cells Proliferation by Anthopleura anjunae Oligopeptide (YVPGP) via PI3K/AKT/mTOR Signaling Pathway. Mar Drugs. 2018 Sep 11;16 (9) :325.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10992/

Peptides

No Development Reported

Bax; Bcl-xL; Caspase 3; Caspase 7; Caspase 8; Caspase 9