YWHAE Antilichaam

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.

7531

P62258

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human YWHAE (NP_006752.1) .

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle, Neuroscience, Signal Transduction, Stem Cell

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 29kDa

IgG

WB: 1:500 - 1:2000

YWHAE

HepG2

NIH/3T3

SH-SY5Y

Mouse kidney

Rat liver

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

Homo sapiens

YWHAE, 14-3-3E, 14-3-3 epsilon, 14-3-3 protein epsilon, MDCR, MDS, KCIP-1

WB

Liquid