Z-13752A

Z-13752A is a mercaptopropanoyl amino acid. Z-13752A inhibits NEP and ACE, with Ki values of 1.8 and 3.2 nM, respectively. Z-13752A decreases the arterial blood pressure and increases coronary blood flow. Z-13752A can be used in the research of coronary artery occlusion[1][2].

193420-09-6

12352005

Angiotensin-converting Enzyme (ACE) ; Neprilysin

Metabolic Enzyme/Protease

Cardiovascular Disease

SC[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=C(C3=NC=CS3)C=C2)C(O)=O)=O

C22H22N2O3S2

426.55

[1]Robl J A, et al. Recent advances in the design and development of vasopeptidase inhibitors[J]. Expert Opinion on Therapeutic Patents, 1999, 9 (12) : 1665-1677. |[2]Venugopal J. Pharmacological modulation of the natriuretic peptide system[J]. Expert Opinion on Therapeutic Patents, 2003, 13 (9) : 1389-1409.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-18209/

Reference compound1

No Development Reported