Z-Doxepine-d3 (Hydrochloride)

Z-Doxepin-d3 hydrochloride is the deuterium labeled 7-Hydroxychlorpromazine hydrochloride. 7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine (HY-12708). 7-Hydroxychlorpromazine hydrochloride can increase prolactin levels in rats. 7-Hydroxychlorpromazine hydrochloride can increase dopamine turnover and has a sedative effect. In addition, 7-Hydroxychlorpromazine hydrochloride can effectively inhibit amphetamine-induced stereotyped behavior in rats and is used in the study of psychosis[1][2].

2469242-68-8

12352005

Dopamine Receptor; Drug Metabolite; Isotope-Labeled Compounds

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Neurological Disease

ClC(C=C1)=CC2=C1SC(C=C(O)C=C3)=C3N2CCCN(C([2H])([2H])[2H])C([2H])([2H])[2H].Cl

C17H14D6Cl2N2OS

377.36

[1]Meltzer H Y, et al. Effect of metabolites of chlorpromazine on plasma prolactin levels in male rats[J]. European Journal of Pharmacology, 1977, 41 (4) : 431-436.|[2]Perry T L, et al. 7-Hydroxychlorpromazine: potential toxic drug metabolite in psychiatric patients[J]. Science, 1964, 146 (3640) : 81-83.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W704752/

Isotope-Labeled Compounds

Phase 2