(Z) -Thiothixeen-d8

(Z) -Thiothixene-d8 (NSC 108165-d8; Navan-d8; Navane-d8) is the deuterium labeled Thiothixene. Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.

NSC 108165-d8; Navan-d8; Navane-d8

12352005

Adrenergic Receptor; Dopamine Receptor; Histamine Receptor; Isotope-Labeled Compounds; mAChR; Sigma Receptor

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Others

O=S(C1=CC2=C(SC3=CC=CC=C3/C2=C\CCN4C([2H])(C([2H])(N(C([2H])(C4([2H])[2H])[2H])C)[2H])[2H])C=C1)(N(C)C)=O

C23H21D8N3O2S2

451.67

[1]Silvestre, et al. Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes. Methods Find. Exp. Clin. Pharmacol. 27 (5), 289-304 (2005) .

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W748758/

Isotope-Labeled Compounds

No Development Reported