Z-Val-Val-Nle-diazomethylketon

Z-Val-Val-Nle-diazomethylketone is a cathepsin S (CATS) inhibitor. Z-Val-Val-Nle-diazomethylketone significantly inhibits the IFNg-induced upregulation of the MHCII molecules HLA-DR and Ii-p33/35 with an increase of Ii-p10 protein level. Z-Val-Val-Nle-diazomethylketone can be used for dermatological diseases like psoriasis, atopic dermatitis and actinic keratosis research[1].

155026-49-6

Z-Val-Val-Nle-CHN2

12352209

Cathepsin; MHC

Immunology/Inflammation; Metabolic Enzyme/Protease

COVID-19-immunoregulation

Inflammation/Immunology

O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCC)C(C=[N+]=[N-])=O)=O)=O

C25H37N5O5

487.59

[1]Schönefuss A, et al. Upregulation of cathepsin S in psoriatic keratinocytes. Exp Dermatol. 2010 Aug;19 (8) :e80-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P5898/

Peptides

No Development Reported

Cathepsin C; MHC II