Zaïre ebolavirus (stam Kikwit-95) VP30 Proteïne (His)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists also stop-start transcription at gene junctions to promote transcription of downstream genes. Interaction with NP plays a critical role in transcription initiation by recognizing the RNA stem loop. Interaction with host RBBP6 interferes with NP-VP30 interaction and inhibits viral RNA synthesis. Also acts as a suppressor of RNA silencing by interacting with host DICER1 and TARBP2/TRBP.
Ice Packs
-20°C
Beschrijving
Zaïre ebolavirus (stam Kikwit-95) VP30 Proteïne (His) Beschikbaar in 5 µg. Bestel eenvoudig online met snelle levering.
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