Zap 70 (Ab 493) Antilichaam

ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the ζ chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-ζ chain, which can mediate the transduction of extracellular stimuli into cellular effector functions

7535

P43403

NP_001070.2

Human, Mouse, Rat

Zap-70 (Ab-493) antibody was raised against a peptide sequence around aa.491~495 (S-Y-Y-T-A) derived from Human ZAP70.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

70 kDa

This antibody detects endogenous level of total Zap-70 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

ZAP70

Zeta-chain (TCR) associated protein kinase 70kDa

Homo sapiens

Chan AC, et al. (1995) EMBO J; 14 (11) : 2499-2508Kong G, et al. (1996) Mol Cell Biol; 16 (9) : 5026-5035Salomon AR, et al. (2003) Proc Natl Acad Sci U S A; 100 (2) : 443-448

SRK, STD, TZK, STCD, ZAP-70, ERBB, ERBB1, HER1, 70 kDa zeta-associated protein, SRK, Syk-related tyrosine kinase, ZA70

WB, IHC

31455611

Liquid