ZAP70 Antilichaam [3D2A4]

ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Zap70 controls TCR (T-cell antigen receptor) -linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the zap-70 gene. ZAP-70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.

7535

P43403

P43403

Human

Ni-NTA purified truncated recombinant ZAP70 expressed in E. Coli strain BL21 (DE3) .

3D2A4

Unconjugated

Primary Antibodies

Signal Transduction, Immunology, Innate Immunity

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

ZAP70 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

ZAP70

Zeta-chain (TCR) associated protein kinase 70kDa

Homo sapiens

Sigal Gelkop , Gerrald D. Gish, Yael Babichev J Immunol. 2005 Dec 15;175 (12) :8123-32.

Joaquim Carreras , Neus Villamor , Lluis Colomo J Pathol. 2005 Mar;205 (4) :507-13.

Claire Hivroz Med Sci (Paris) . 2005 Feb;21 (2) :150-5.

SRK, 70 kDa zeta-chain associated proteinSRK, STD, TZK, STCD, ZAP-70

ELISA, WB, IHC

1177044