ZBTB7A Antilichaam

ZBTB7A Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB7A, also known as LRF, was initially identified as a potential target of the LAZ-3/BCL-6 oncogene. Later reports demonstrated that it could bind to the wild-type IST (inducer of short transcripts) elements of HIV-1 long terminal repeats (LTRs) and stimulate Tat activity on the HIV-1 LTR. More recently it ZBTB7A has been recognized as a proto-oncogene whose overexpression contributes to malignancy in breast cancer and functions as a co-repressor of the androgen receptor in prostate cancer cells.

51341

O95365

AAH84568

Human, Mouse

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

ZBTB7A Antibody is affinity chromatography purified via peptide column.

Cat. No. 1316 - Human Ovary Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (94%), Chicken: (88%)

ZBTB7A Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ZBTB7A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of ZBTB7A are known to exist; this antibody will recognize both isoforms. This antibody is predicted to not cross-react with other ZBTB protein family members.

ZBTB7A

Cat. No. 11-201 - Human Ovary Tissue Slide

Zinc finger and BTB domain containing 7A

Homo sapiens

Filion GJP, Zhenilo S, Salozhin S, et al. A family of zinc finger proteins that bind methylated DNA and repress transcription. Mol. Cell. Biol.2006; 26:169-81.

Davies JM, Hawe N, Kabarowski J, et al. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. Oncogene1999; 18:365-75.

Pendergrast PS, Wang C, Hernandez N, et al. FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles. Mol. Cell. Biol.2002; 13:915-29.

Qu H, Qu D, Chen F, et al. ZBTB7 overexpression contributes to malignancy in breast cancer. Cancer Invest.2010; 28:672-8.

ZBTB7A Antibody: LRF, FBI1, FBI-1, ZBTB7, ZNF857A, pokemon, LRF, Zinc finger and BTB domain-containing protein 7A, Factor binding IST protein 1

ELISA, WB, IHC-P, IF

7705375

Liquid