ZC3H12A (CT) Antilichaam

ZC3H12A Antibody: ZC3H12A is an MCP1 (CCL2; MIM 158105) -induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis. ZC3H12A inhibits the Wnt/beta-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs. ZC3H12A ribonuclease can bind and cleave AURKA mRNA in MYCN-amplified neuroblastoma cells. ZC3H12A is a novel link between diabetogenic conditions and impaired insulin secretory capacity. ZC3H12A overexpression in human neuroblastoma cell lines causes cell-cycle arrest by G1/S checkpoint block.

80149

Q5D1E8

Q5D1E7.2

Human, Mouse, Rat

9547

Unconjugated

Primary Antibodies

Innate Immunity

ZC3H12A Antibody is affinity chromatography purified via peptide column.

Cat. No. 1701-01 - Human Lung Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chimpanzee (100%) ; Monkey (100%) ; Pig (79%) ; Chicken (83%)

ZC3H12A Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ZC3H12A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human ZC3H12A has one isoform (599aa, 65.7kD) . Mouse has one isoform (596aa, 65.6kD) . Rat has one isoform (596aa, 65.9kD) . 9547 can detect ZC3H12A in human, mouse, and rat.

ZC3H12A

Cat. No. 11-701 - Human Testis Tissue Slide

Zinc finger CCCH-type containing 12A

Homo sapiens

Gorka et al. Oncogene. 2021; 40 (50) :6720-6735

Nowak et al. RNA Biol. 2021; 18 (1) :144-156

Tyka et al. Biochim Biophys Acta Mol Basis Dis. 2021; 1867 (10) :166199

Boratyn et al. J Cell Biochem. 2020; 121 (5-6) ;3406-3425

ZC3H12A Antibody: Endoribonuclease ZC3H12A, Monocyte chemotactic protein-induced protein 1, MCP-induced protein 1, MCPIP-1, Zinc finger CCCH domain-containing protein 12A

ELISA, WB, IF, IHC

190485853

Liquid