ZD-2767
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ZD-2767 is an antibody-directed enzyme prodrug therapy (ADEPT) agent. ZD-2767 is composed of the prodrug ZD2767P, carboxypeptidase G2 (CPG2), and the active drug ZD2767D. ZD-2767 achieves tumor-targeted drug delivery through an innovative ADEPT strategy, triggering apoptosis of cancer cells by causing irreparable DNA damage. ZD-2767 can be used for cancer research[1].
156079-88-8
12352005
Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis
Apoptosis; Cell Cycle/DNA Damage
Cancer
O=C(O)CC[C@@H](C(O)=O)NC(OC1=CC=C(N(CCI)CCI)C=C1)=O
C16H20I2N2O6
590.15
[1]Monks NR, et al. Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue. Br J Cancer. 2001 Sep 1;85 (5) :764-71.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19208/
Reference compound1
Phase 1
Beschrijving
ZD-2767 is an antibody-directed enzyme prodrug therapy (ADEPT) agent. ZD-2767 is composed of the prodrug ZD2767P, carboxypeptidase G2 (CPG2), and the active dru
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