Zebrafish Psmd7 Antilichaam / 26S proteasoom niet-ATPase regelgevende subeenheid 7

In zebrafish, Psmd7 is the ortholog of the human PSMD7 gene, sharing a high degree of sequence similarity and functional conservation. The zebrafish and human versions of Psmd7 contain similar domains that allow interaction with other proteasomal subunits, enabling the proper assembly and function of the 26S proteasome complex. This functional conservation underscores the relevance of zebrafish as a model organism for studying proteasomal processes and their role in human health. Psmd7 in zebrafish may have isoforms resulting from alternative splicing, although specific isoforms may not be fully characterized. These isoforms could play roles in different tissues or developmental stages, contributing to the fine-tuning of proteasomal activity. Isoform variation could also provide differential regulation of proteasome function in response to environmental stress, cellular signaling, or developmental needs. In zebrafish, Psmd7 is expressed in a variety of tissues, especially those with high protein turnover, such as the brain, liver, and kidney. This expression pattern reflects the protein's essential role in controlling protein degradation, supporting cellular functions such as stress response, apoptosis, and differentiation. Given the high conservation between zebrafish Psmd7 and human PSMD7, the zebrafish model is valuable for studying proteasomal dysfunctions that contribute to diseases in humans, such as cancer, neurodegenerative disorders, and immune dysfunctions. Disruption in PSMD7 has been linked to altered proteasomal activity, which can lead to the accumulation of damaged proteins and cellular stress. The zebrafish model can be used to explore potential therapeutic approaches aimed at modulating proteasomal function and preventing the pathological effects associated with these diseases.

Western Blot: 0.5-1 µg/mL

Q7ZYX7

Zebrafish

E. coli-derived zebrafish Psmd7 recombinant protein (amino acids M1-N274) was used as the immunogen for the Zebrafish Psmd7 antibody.

WB

Antigen affinity chromatography

Antigen affinity purified

Lyophilized from 1X PBS with 2% Trehalose

This Zebrafish Psmd7 antibody is available for research use only.

After reconstitution, the Zebrafish Psmd7 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Optimal dilution of the Zebrafish Psmd7 antibody should be determined by the researcher.

Western blot analysis of Psmd7 protein using Zebrafish Psmd7 antibody and 1) zebrafish head, 2) whole female zebrafish, 3) whole male zebrafish and 4) zebrafish embryo tissue lysate. Predicted molecular weight ~37 kDa.