Zebravis Klhl12 Antilichaam / Kelch-achtig eiwit 12

Kelch-like protein 12 is a protein that in humans is encoded by the KLHL12 gene. This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants.

Western blot: 0.5-1 µg/mL

Q5U374

Zebrafish

An E.coli-derived zebrafish Klhl12 recombinant protein (amino acids R23-V327) was used as the immunogen for the Zebrafish Klhl12 antibody.

WB

Antigen affinity chromatography

Antigen affinity purified

Lyophilized from 1X PBS with 2% Trehalose

This Zebrafish Klhl12 antibody is available for research use only.

After reconstitution, the Zebrafish Klhl12 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Optimal dilution of the Zebrafish Klhl12 antibody should be determined by the researcher.

Western blot analysis of Klhl12 protein using Klhl12 antibody and zebrafish embryo tissue lysate. The predicted molecular weight of Klhl12 is ~63 kDa.