ZFPM1 Antilichaam - middengebied: Biotine (ARP32193 P050-Biotine)

Zinc finger protein, multitype 1

FOG, FOG1, ZNF408, ZNF89A, ZC2HC11A

161882

Q8IX07

NP_722520

Human, Rat, Cow

The immunogen is a synthetic peptide directed towards the middle region of human ZFPM1

ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.

GSK3B; CTBP2; TRIM21; MTA1; RBBP4; Rb1; GATA1; GIPC1; TOP3B; GATA2

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 91%; Human: 100%; Rat: 83%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

105kDa

Sugiyama, D., (2008) Blood 111 (4), 1924-1932

Wet Ice

1006

ZFPM1

ZFPM1

Rabbit

Zinc finger protein ZFPM1

NM_153813

PPPPPPGHAPAPESPRPGSGSGSGPGLAPARSPGPAADGPIDLSKKPRRP