Zileuton
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Zileuton is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO) .1 It also inhibited leukotriene B4 biosynthesis (IC50’s = 400nM rat PMNL, 400nM human PMNL and 900nM human whole blood) .1 Zileuton suppressed prostaglandin biosynthesis via interference with arachidonic acid release in macrophages independent of 5-LO inhibition (IC50 = 13 µM PGE2 inhibition in LPS-stimulated whole blood) .2 Zileuton was approved by the FDA in 1997 for the treatment of asthma (ZYFLO) .
Unconjugated
White solid
-20°C
Beschrijving
Zileuton Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
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