ZIMP10 Antilichaam

ZIMP10 Antibody: ZIMP10, also known as ZMIZ1, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription) -like protein initially identified as a transcriptional co-activator of the androgen receptor (AR) . ZIMP10 and the related protein ZIMP7 interact with PIAS3 and enhances AR-mediated transcription. Later experiments showed that ZIMP10 is also a co-activator of the p53 tumor suppressor. Mice deficient in ZIMP10 result in embryonic lethality by E10.5; these embryos reveal severe defects in the reorganization of the yolk sac vascular plexus, indicating that ZIMP10 plays an important role in proper vascular development.

57178

Q9ULJ6

NP_65071

Human

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

ZIMP10 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (92%)

ZIMP10 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ZIMP10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms are known to exist; this antibody will recognize all three. ZIMP10 antibody is predicted to not cross-react with other PIAS protein family members.

ZMIZ1

Cat. No. 17-004 - K-562 Cell Slide

Zinc finger, MIZ-type containing 1

Homo sapiens

Sharma M, Li X, Wang Y, et al. hZimp10 is an androgen receptor co-activator and forms a complex with sUMO-1 at replication foci. EMBO J. 2003; 22:6101-14.

Beliakoff J and Sun Z. Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators. Nucl. Recept. Signal. 2006; 4:e017.

Lee J, Beliakoff J, and Sun Z. The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor. Nuc. Acids Res. 2007; 35:4523-34

Beliakoff J, Lee J, Ueno H, et al. The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. Mol. Cell. Biol. 2008; 28:282-92.

ZIMP10 Antibody: MIZ, RAI17, ZIMP10, hZIMP10, TRAFIP10, KIAA1224, Zinc finger MIZ domain-containing protein 1, PIAS-like protein Zimp10

ELISA, WB, ICC, IF

31543543

Liquid