ZIMP7 Antilichaam

ZIMP7 Antibody: ZIMP7, also known as ZMIZ2, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription) -like protein and a transcriptional coactivator. ZIMP7 is expressed most abundantly in testis. The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity and this activity is inhibited by the N-terminus in the full-length ZIMP7. ZIMP7 and the related protein ZIMP10 interact with PIAS3 and enhances Androgen Receptor (AR) - mediated transcription. The interaction between ZIMP7 and SWI/SNF complex suggests a possible role for ZIMP7 in chromatin modification.

83637

Q8NF64

Q8NF64

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction

ZIMP7 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

ZIMP7 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ZIMP7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least four isoforms are known to exist. ZIMP7 antibody is predicted to not cross-react with other PIAS protein family members.

ZMIZ2

Zinc finger, MIZ-type containing 2

Homo sapiens

Huang CY, Beliakoff J, Li X, et al. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Mol. Endocrinol. 2005; 19:2915-29

Ueki N, Oda T, Kondo M, et al. Selection system for genes encoding nuclear-targeted proteins. Nat. Biotechnol. 1998; 16:1338-42.

Beliakoff J and Sun Z. Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators. Nucl. Recept. Signal. 2006; 4:e017

Peng Y, Lee J, Zhu C, et al. A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. J. Biol. Chem. 2010; 285:11465-75.

ZIMP7 Antibody: NET27, ZIMP7, hZIMP7, TRAFIP20, KIAA1886, HRIHFB2007, Zinc finger MIZ domain-containing protein 2, PIAS-like protein Zimp7

ELISA, WB

54607108

Liquid