ZIP1 Antilichaam

ZIP1 Antibody: ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κ B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.

27173

Q9NY26

NP_055252

Human, Mouse

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

ZIP1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1405 - Mouse Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (88%)

ZIP1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ZIP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of ZIP1 are known to exist; this antibody will detect both isoforms. ZIP1 antibody is predicted not to cross-react with other ZIP family proteins.

SLC39A1

Cat. No. 10-401 - Human Kidney Tissue Slide

Solute carrier family 39 (zinc transporter), member 1

Homo sapiens

Lioumi M, Ferguson CA, Sharpe PT, et al. Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. Genomics 1999; 62:272-80.

Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch. 2004; 447:796-800.

Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta. 2003; 1611:16-30.

Costello LC and Franklin RB. The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots. Mol. Cancer. 2006; 5:17.

ZIP1 Antibody: ZIP1, ZIRTL, IRT1, ZIP1, CGI-08, CGI-71, Zinc transporter ZIP1, Solute carrier family 39 member 1, ZIP-1

ELISA, WB, IHC-P, IF

21361423

Liquid