ZIP6 Antilichaam

ZIP6 Antibody: The zinc transporter ZIP6, also known as SLC39A6, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP6 expression has also been reported in human cervical cancer and the HeLa cell line; down-regulation of ZIP6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.

25800

Q13433

NP_001092876

Human, Mouse

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

ZIP6 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1402 - Mouse Lung Tissue Lysate

1 mg/mL

ZIP6 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ZIP6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SLC39A6

Solute carrier family 39 (zinc transporter), member 6

Homo sapiens

Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50.

Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.

Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.

Taylor KM. LIV-1 breast cancer protein belongs to new family of histidine-rich membrane proteins with potential to control intracellular ZN2+ homeostasis. IUBMB Life2000; 49:249-53.

ZIP6 Antibody: LIV-1, LIV1, ZIP6, Zinc transporter ZIP6, Estrogen-regulated protein LIV-1, ZIP-6

ELISA, WB, IHC-P, IF

153252214

Liquid