ZIP7 Antilichaam

ZIP7 Antibody: The zinc transporter ZIP7, also known as SLC39A7, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP7 was initially identified while characterizing genes in the major histocompatibility complex on chromosome 17. ZIP7 mRNA is abundantly and widely expressed and the protein localizes to the Golgi apparatus. It functions to transport intracellular zinc from the Golgi apparatus to the cytoplasm of the cell. ZIP7 expression is expressed by zinc. ZIP7 has been suggested to act a hub for tyrosine kinase activation and may thus be a potential therapeutic target for diseases such as cancer where prevention of tyrosine kinase activation would be advantageous.

7922

Q92504

NP_001070984

Human, Mouse, Rat

6093

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 1) shows similar ZIP7 expression profile in human cell lines detected by two independent anti-ZIP7 antibodies that recognize different epitopes, 6093 against N-terminus domain and 24-029 against recombinant fusion protein. ZIP7 proteins are detected in all tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines6093 24-029

Cancer, Cell Cycle

ZIP7 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1403 - Mouse Brain Tissue Lysate

1 mg/mL

ZIP7 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ZIP7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human ZIP7 has one isoform (469aa, 50kD) . Mouse ZIP7 has one isoform (476aa, 51kD) and Rat ZIP7 also has one isoform (468aa, 50kD) . 6093 can detect human, mouse and rat.

SLC39A7

Cat. No. 10-301 - Human Brain Tissue Slide

Cat. No. 1204 - K562 Cell Lysate

Cat. No. 1212 - 3T3 (Balb) Cell Lysate

Solute carrier family 39 (zinc transporter), member 7

Homo sapiens

Dufner-Beattie et al. J. Biol. Chem.2003; 278:50142-50.

Eide. Pflugers Arch.2004; 447:796-800.

Taylor and Nicohlson. Biochim. Biophys. Acta.2003; 1611:16-30.

Lai et al. Genomics1994; 23:338-42.

ZIP7 Antibody: KE4, HKE4, ZIP7, RING5, H2-KE4, D6S115E, D6S2244E, Zinc transporter SLC39A7, Histidine-rich membrane protein Ke4

ELISA, WB, IHC-P, IF

117553619

Liquid