ZMYM3 Antilichaam

ZMYM3 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM3 is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation.

9203

Q14202

AAH69057

Human, Mouse

Unconjugated

Primary Antibodies

Homeostasis

ZMYM3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

ZMYM3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ZMYM3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of ZMYM3 are known to exist; this antibody will detect all three. ZMYM3 antibody is predicted to not cross-react with other ZMYM protein family members.

ZMYM3

Cat. No. 10-301 - Human Brain Tissue Slide

Zinc finger, MYM-type 3

Homo sapiens

Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.

Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature2006; 441:315-21

Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→ q12. Cytogenet. Cell Genet.2000; 89:24-8.

Van der Maarel SM, Scholten IH, Huber I, et al. Cloning and characterization of DSX6673E, a candidate gene for X-linked mental retardation in Xq13.1. Hum. Mol. Gen.1996; 5:887-97.

ZMYM3 Antibody: MYM, XFIM, ZNF261, DXS6673E, ZNF198L2, KIAA0385, Zinc finger MYM-type protein 3, Zinc finger protein 261

ELISA, WB, IF

119625706

Liquid