ZMYM4 Antilichaam

ZMYM4 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. It has been found to be overexpressed in human lung adenocarcinomas and squamous cell carcinomas, and the overexpression of a fragment of the 3'UTR of the ZMYM4 mRNA termed Cell Death Inhibiting RNA (CDIR) protects HeLa cells from IFN-γ -induced apoptosis, suggesting that ZMYM4 may play a role in tumorigenesis.

9202

Q5VZL5

AAI27114

Human

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

ZMYM4 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (94%)

ZMYM4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ZMYM4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

167 kDa

IgG

At least three isoforms of ZMYM4 are known to exist; this antibody will detect all of them. ZMYM4 antibody is predicted not to cross-react with other ZMYM family members.

ZMYM4

Zinc finger, MYM-type 4

Homo sapiens

Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn. 1993; 11:557-70.

Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature 2006; 441:315-21.

Sohal J, Reiter A, Goldman JM, et al. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11→ q12. Cytogenet. Cell Genet. 2000; 89:24-8.

McDoniels-Silvers AL, Nimri CF, Stoner GD, et al. Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin. Cancer Res. 2002; 8:1127-38.

ZMYM4 Antibody: MYM, CDIR, ZNF262, ZNF198L3, KIAA0425, Zinc finger MYM-type protein 4, Zinc finger protein 262

ELISA, IHC-P

117558167

Liquid