ZNF496 Antilichaam - middengebied: Biotine (ARP30024_P050-Biotine)

Zinc finger protein 496

NIZP1, ZFP496, ZSCAN49, ZKSCAN17

84838

Q96IT1

NP_116141

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the middle region of human ZNF496

ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn (II) -dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.

ZKSCAN4; ZSCAN22; ZNF483; ZNF446; ZSCAN12; ZSCAN21; ARR3; Nsd1; SUMO2; UBC; CBX3; TRIM28; NR3C1; POLR3D; ZZZ3; JADE2; RAI1; SSX3; SUPT5H; PPARG

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 86%; Dog: 93%; Horse: 86%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%; Sheep: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

67kDa

Nielsen, A.L., (2004) Mol. Cell. Biol. 24 (12), 5184-5196

Wet Ice

587

ZNF496

ZNF496

Rabbit

Zinc finger protein 496

NM_032752

QEKPHECSVCGELFSDSEDLDGHLESHEAQKPYRCGACGKSFRLNSHLLS