Zotatifin
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2098191-53-6
EFT226
C13845-1mg
EIF
Cell Cycle
CN (C) CC1C (C2 (C (C1O) (C3=C (N=C (C=C3O2) OC) OC) O) C4=CC=C (C=C4) C#N) C5=CC=CC=C5
C28H29N3O5
Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity.
Beschrijving
Zotatifin Beschikbaar in 1 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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