Zotepine-d6

Zotepine-d6 is the deuterium labeled Zotepine. Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo[1][2].

2512222-52-3

12352005

5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Neurological Disease

ClC1=CC2=C(SC3=C(C=C2OCCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C=CC=C3)C=C1

C18H12D6ClNOS

337.90

[1]Richelson E, et, al. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68 (1) :29-39.|[2]Yamamura S, et, al. Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex. Br J Pharmacol. 2009 Jun;157 (4) :656-65.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W744038/

Isotope-Labeled Compounds

No Development Reported