ZP3 Antilichaam - C-terminaal gebied: Biotine (ARP35855_T100-Biotine)

Zona pellucida glycoprotein 3 (sperm receptor)

ZPC, ZP3A, ZP3B, Zp-3, OOMD3

7784

P21754-2

Human, Rat, Cow, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human ZP3

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene

HECW2; OR2L13; SPACA3; MICALL1; MRPS16; PCDH17; UBAP2L; UBC; ENGASE; ACR; FURIN

Biotin

Polyclonal Antibody

WB

0.5 mg/ml

Cow: 100%; Horse: 100%; Human: 100%; Rabbit: 100%; Rat: 90%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

47kDa

Chamberlin, M.E., et al., (1990) Proc. Natl. Acad. Sci. U.S.A. 87 (16), 6014-6018

Wet Ice

424

ZP3

ZP3

Rabbit

Zona pellucida sperm-binding protein 3

NKGDCGTPSHSRRQPHVMSQWSRSASRNRRHVTEEADVTVGATDLPGQEW