ZSCAN4 Antilichaam

ZSCAN4 Antibody: Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.

201516

Q8NAM6

NP_689890.1

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

ZSCAN4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1402 - Mouse Lung Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (81%), Chicken: (86%)

ZSCAN4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ZSCAN4 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

ZSCAN4

Zinc finger and SCAN domain containing 4

Homo sapiens

Hamatani T, Carter MG, Sharov AA, et al. Dynamics of global gene expression changes during mouse preimplantation development. Dev. Cell 2004; 6:117-131.

Falco G, Lee SL, Stanghellini I, et al. Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells. Dev. Biol. 2007; 307:539-50.

Zalzman M, Falco G, Sharova LV, et al. Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 2010; 464:858-63.

ZSCAN4 Antibody: ZNF494, ZNF494, Zinc finger and SCAN domain-containing protein 4, Zinc finger protein 494

ELISA, WB, IHC-P, IF

22749365

Liquid