ACVR2A-eiwit (C-His, mens)

ACVR2A

ACTRII, ACVR2

C-His

< 1.0 EU per μg of the protein as determined by the LAL method

≥ 97 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

1.Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 0.4-3 μg/mL in the presence of 10 ng/mL recombinant Activin A (Routinely tested) . 2.Immobilized Recombinant Human ACVR2 / ACTRII / ACVR2A Protein (His Tag) (Cat: 10257-H08H) at 5 μg/mL (100 μL/well) can bind Recombinant Human/Mouse/Rat Cynomolgus/Rhesus Activin A/INHBA Protein, Biotinylated (Cat: 10429-HNAH-B), the EC50 is 15-45 ng/mL (Routinely tested) . 3.Recombinant Human ACVR2 / ACTRII / ACVR2A Protein (His Tag) (Cat: 10257-H08H) immobilized on CM5 chip, can bind Recombinant Human/Mouse/Rat/Cynomolgus/Rhesus Activin A/INHBA Protein (Cat: 10429-HNAH) with an affinity constant of 0.504 nM as determined in an SPR assay (Biacore 8K) (Routinely tested) .

Met1-Pro134

The recombinant human ACVR2A comprises 126 amino acids and predicts a molecular mass of 14.9 kDa. As a result of glycosylation, the apparent molecular mass of the protein is approximately 35-40 kDa in SDS-PAGE under reducing conditions.

Human