AICDA (NM 020661) Humaan Recombinant eiwit

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. AICDA is specifically expressed and active in germinal center-like B cells. In the germinal center, AICDA is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. An epigenetic role in neoplastic transformation and lymphoma progression has been experimentally ascribed to AICDA using mouse models. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2) . [provided by RefSeq, Jul 2020]

Purified recombinant protein of Human activation-induced cytidine deaminase (AICDA), full length, with N-terminal His tag, expressed in E. coli, 50ug

AID; ARP2; CDA2; HEL-S-284; HIGM2

57379

Q9GZX7, Q546Y9, Q7Z599

NM_020661

12p13.31

E. coli

N-His

Primary immunodeficiency

Primary immunodeficiency

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0.

Druggable Genome

23.8 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

AICDA

Human

NP_065712

https://www.ncbi.nlm.nih.gov/gene/57379

https://www.uniprot.org/uniprot/Q9GZX7

https://www.ncbi.nlm.nih.gov/nuccore/NM_020661

https://www.ncbi.nlm.nih.gov/nuccore/NP_065712