Anti-Acid fosfatase/ACP1 Antibody Picoband® fluoro594 Vervoeging

Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene. The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Platelet-activating factor acetylhydrolase; PAF acetylhydrolase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; Group-VIIA phospholipase A2; gVIIA-PLA2; LDL-associated phospholipase A2; LDL-PLA (2) ; PAF 2-acylhydrolase; PLA2G7; PAFAH

ACP1

52

P24666

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Acid phosphatase/ACP1 recombinant protein (Position: M1-H158) .

Plasma.

Flow Cytometry

Cardiovascular, Immunology, Innate Immunity, Macrophage/Inflammation, Platelets, Secreted Molecules

Immunogen affinity purified.

Liquid

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

1. Arnaud, J., Vavrusa, B., Sevin, J., Constans, J. Human red-cell acid phosphatase (ACP1) : a new mutant (ACP1*KUK) detected by isoelectric focusing, kinetics of thermostability and substrate activity. Hum. Hered. 39: 288-293, 1989. 2. Arnaud, J., Vavrusa, B., Wiederanders, G., Constans, J. Human red-cell acid phosphatase (ACP1) : kinetic and thermodynamic characterization of the KUK variant. Hum. Hered. 42: 140-142, 1992. 3. Beemer, F. A., van der Heiden, C., Van Hemel, J. O., Jansen, M. Letter to the editors. (Letter) Clin. Genet. 24: 151, 1983.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

63692 MW

6

Phospholipase A2 group VII

Secreted, extracellular space.

Sentrin-specific protease 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.