TRPM4-IN-1

TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer[1][2].

351424-20-9

CBA

12352005

H302, H312, H332

TRP Channel

Reference compound

Membrane Transporter/Ion Channel; Neuronal Signaling

Cancer-programmed cell death

Cancer; Cardiovascular Disease

https://www.medchemexpress.com/trpm4-in-1.html

99.98

DMSO : 83.33 mg/mL (ultrasonic)

O=C(O)C1=CC=C(Cl)C=C1NC(COC2=CC=CC=C2Cl)=O

C15H11Cl2NO4

340.16

H302, H312, H332

[1]Lijo Cherian Ozhathil, et al. Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br J Pharmacol. 2018 Jun; 175 (12) : 2504–2519.|[2]Clémence Delalande, et al. Optimizing TRPM4 inhibitors in the MHFP6 chemical space. Eur J Med Chem. 2019 Mar 15;166:167-177.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-122605/TRPM4-IN-1-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported