Anti-AHA1/AHSA1 Antibody Picoband® fluoro488 Vervoeging

Activator of 90 kDa heat shock protein ATPase homolog 1 is an enzyme that in humans is encoded by the AHSA1 gene. The International Radiation Hybrid Mapping Consortium mapped the AHSA1 gene to chromosome 14. It acts as a co-chaperone of HSP90AA1. AHSA1 competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins

Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1; p38; AHSA1; C14orf3; HSPC322

AHSA1

10598

O95433

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human AHA1/AHSA1 recombinant protein (Position: E221-L264) .

Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.

Flow Cytometry

Chaperones, Golgi Proteins, Protein Trafficking, Signal Transduction

Immunogen affinity purified.

Liquid

Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360) .

1. Entrez Gene: AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) . 2. Lotz, G. P., Lin, H., Harst, A., Obermann, W. M. J. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. J. Biol. Chem. 278: 17228-17235, 2003. 3. Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, Prodromou C (Dec 2002) . Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Mol. Cell. 10 (6) : 1307–18.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

101272 MW

6

Activator of HSP90 ATPase activity 1

Cytoplasm, cytosol.

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.