Anti-alfa 1 Fetoproteïne/AFP Antibody Picoband® fluoro647 Vervoeging

AFP, also called Alpha-fetoprotein; alpha-fetoprotein, is a protein that in humans is encoded by the AFP gene. It is mapped to 4q13.3. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. In rodents AFP binds estradiol to prevent the transport of this hormone across the placenta to the fetus. The main function of this is to prevent the virilization of female fetuses. Moreover, it has an important role as a diagnostic marker, especially in certain tumors and liver diseases of childhood. AFP is also used to test the potential usefulness of plasma alpha fetoprotein determination as a diagnostic marker in biliary atresia, hepatitis, and yolk sac derived tumours.

Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin; Afp

AFP

174

P02771

Human

No cross-reactivity with other proteins.

E.coli-derived human alpha 1 Fetoprotein/AFP recombinant protein (Position: R19-L258) .

Plasma.

Flow Cytometry

Cancer, Cardiovascular, Developmental Biology, Organogenesis, Serum Proteins, Tumor Antigens, Tumor Biomarkers

Immunogen affinity purified.

Liquid

Binds estrogens, fatty acids and metals.

1. Carter CS (2002) . Neuroendocrinology of sexual behavior in the female. In Becker JB. Behavioral Endocrinology. Cambridge, Mass: MIT Press. pp.88-89. ISBN 0-262-52321-3 2. Bader D, Riskin A, Vafsi O, Tamir A, Peskin B, Israel N, Merksamer R, Dar H, David M (November 2004) . Alpha-fetoprotein in the early neonatal period--a large study and review of the literature. Clin. Chim. Acta 349 (1-2) : 15–23. 3. Blair JI, Carachi R, Gupta R, Sim FG, McAllister EJ, Weston R (April 1987) . Plasma alpha fetoprotein reference ranges in infancy: effect of prematurity. Arch. Dis. Child. 62 (4) : 362–9.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Alpha-fetoprotein

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.