Anti-Angiostatine K1-3/PLG Antilichaam Picoband® 31.0550 Vervoeging

Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth. It displays increased inhibitory activity (ED50 = 70nM) relative to kringles 1-4 (ED50 = 135nM) .

Plasminogen;3.4.21.7; Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B; PLG

PLG

5340

P00747

Human

No cross-reactivity with other proteins

E. coli-derived human Angiostatin K1-3 recombinant protein (Position: C103-C352) .

Present in plasma and many other extracellular fluids. It is synthesized in the liver.

Flow Cytometry

Protease Inhibitors, Proteolysis/Ubiquitin, Proteolytic Enzymes

Immunogen affinity purified.

Liquid

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. .

1. Forsgren, M., Raden, B., Israelsson, M., Larsson, K., Heden, L.-O. Molecular cloning and characterization of a full-length cDNA clone for human plasminogen. FEBS Lett. 213: 254-260, 1987. 2. Miyata, T., Iwanaga, S., Sakata, Y., Aoki, N. Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site. Proc. Nat. Acad. Sci. 79: 6132-6136, 1982.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

90569 MW

No cross reactivity with other proteins.

6

Plasminogen

Secreted . Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.

Belongs to the peptidase S1 family. Plasminogen subfamily.

Plasminogen

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.