Anti-Angiotensineogeen/AGT Antilichaam Picoband® fluoro488 Vervoeging

AGT (ANGIOTENSINOGEN), also called SERPINA8, is an alpha-2-globulin that is produced constitutively and released into the circulation mainly by the liver. ATG is a member of the serpin family, although it is not known to inhibit other enzymes, unlike most serpins. Angiotensinogen is also known as renin substrate. The AGT gene is mapped on 1q42.2. And the human angiotensinogen gene contains 5 exons. The expression of AGT and enzymes required for its conversion to angiotensin II in human adipose tissue. Western blot analysis showed a distinct band of expected size of the angiotensinogen protein (61 kD) in isolated adipocytes. The more pronounced AGT increase in TT subjects resulted in similar plasma renin activity at a lower plasma active renin concentration, with a higher plasma renin activity/active renin ratio.

Angiotensinogen; Serpin A8; Angiotensin-1; Angiotensin 1-10; Angiotensin I; Ang I; Angiotensin-2; Angiotensin 1-8; Angiotensin II; Ang II; Angiotensin-3; Angiotensin 2-8; Angiotensin III; Ang III; Des-Asp[1]-angiotensin II; Angiotensin-4; Angiotensin 3-8; Angiotensin IV; Ang IV; Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4; Agt; Serpina8

AGT

183

P11859

Mouse

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of mouse Angiotensinogen, identical to the related rat sequence.

Expressed by the liver and secreted in plasma.

Flow Cytometry

Cardiovascular, G Protein Signaling, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.

1. Abonia, J. P., Abel, K. J., Eddy, R. L., Elliott, R. W., Chapman, V. M., Shows, T. B., Gross, K. W. Linkage of Agt and Actsk-1 to distal mouse chromosome 8 loci: a new conserved linkage. Mammalian Genome 4: 25-32, 1993. 2. Arakawa, K., Minohara, A., Yamada, J., Nakamura, M. Enzymatic degradation and electrophoresis of human angiotensin I. Biochim. Biophys. Acta 168: 106-112, 1968. 3. Basso N, Terragno NA (December 2001) . History about the discovery of the renin-angiotensin system. Hypertension 38 (6) : 1246–9.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

51990 MW

No cross reactivity with other proteins.

6

Angiotensinogen

Secreted.

Belongs to the ku70 family.

Angiotensinogen

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.