Anti-Aquaporine 5/AQP5 Antibody Picoband® fluoro550 Vervoeging

Aquaporin 5, also known as AQP5, is a water channel protein. The aquaporins (AQPs) are a family of more than 10 homologous water transporting proteins expressed in many mammalian epithelia and endothelia. At least five AQPs are expressed in the eye: AQP0 (MIP) in lens fiber, AQP1 in cornea endothelium, ciliary and lens epithelia and trabecular meshwork, AQP3 in conjunctiva, AQP4 in ciliary epithelium and retinal Mü ller cells, and AQP5 in corneal and lacrimal gland epithelia. Among the seven human aquaporins cloned to date (AQPs 0-6), genes encoding the four most closely related aquaporins (AQP0, AQP2, AQP5, and AQP6) have been mapped to chromosome band 12q13, suggesting an aquaporin family gene cluster at this locus. Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions.

Aquaporin-5; AQP-5; Aqp5

AQP5

11830

Q9WTY4

Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of mouse AQP5, identical to the related rat sequence.

Flow Cytometry

Cancer, Channels, Metabolism, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.

1. Verkman AS (2003) . Role of aquaporin water channels in eye function.. Exp. Eye Res. 76 (2) : 137–43. 2. Ma T, Yang B, Umenishi F, Verkman AS (1997) . Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13.. Genomics 43 (3) : 387–9.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

28274 MW

No cross reactivity with other proteins.

6

Aquaporin-5

Membrane; Multi-pass membrane protein.

Aquaporin-5 (AQP-5)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.