Anti-Aquaporine 8/AQP8 Antibody Picoband® fluoro647 Vervoeging

AQP8, also known as Aquaporin-8, is a protein that in humans is encoded by the AQP8 gene. Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0) . Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. The AQP8 gene contains 6 exons. It is mapped to chromosome 16p12. Northern blot analysis of human tissues detected a 1.35-kb AQP8 mRNA only in pancreas and colon.

Aquaporin-8; AQP-8; AQP8

AQP8

343

O94778

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human Aquaporin 8.

Expressed only in pancreas and colon.

Flow Cytometry

Cancer, Channels, Metabolism, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.

1. Huang J, et al. Expression of aquaporin 8 in human fetal membrane and placenta of idiopathic polyhydramnios]. Zhonghua Fu Chan Ke Za Zhi, 2009 Jan. 2. Larocca MC, et al. Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport. Am J Physiol Gastrointest Liver Physiol, 2009 Jan. 3. Zhu X, et al. The expression of aquaporin 8 and aquaporin 9 in fetal membranes and placenta in term pregnancies complicated by idiopathic polyhydramnios. Early Hum Dev, 2010 Oct.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

27381 MW

No cross reactivity with other proteins.

6

Aquaporin-8

Membrane; Multi-pass membrane protein.

Belongs to the annexin family.

Aquaporin-8 (AQP-8)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.