Anti-C-C chemokine receptor type 5 CCR5 Antibody Picoband® fluoro594 Vervoeging

Human CC chemokine receptor 5 (CCR5), which is 17.5 kb from the CMKBR2 gene, encodes a 352-amino acid protein with a calculated molecular mass of 40,600 Da. It is organized into four exons and two introns. Human CCR5 is a co-receptor for macrophage-tropic strains of human immunodeficiency virus (HIV) -1 and is expressed by bone-marrow-derived cells. CCR5 is expressed on neurons, astrocytes, and microglia in the central nervous system, and on epithelium, endothelium, vascular smooth muscle and fibroblasts in other tissues. Functionally, CCR5 mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1.

C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; MIP-1 alpha receptor; CD195; Ccr5; Cmkbr5

CCR5

12774

P51682

Mouse

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of mouse CCR5.

Flow Cytometry

Alzheimer's Disease, Antiviral Signaling, Atherosclerosis, Cancer, Cardiovascular, Chemokines, G Protein Signaling, Host-Virus Interaction, Immune System Diseases, Immunology, Innate Immunity, Interspecies Interaction, Macrophage/Inflammation, Microbiology, Neurodegenerative Disease, Neurology Process, Neuroscience, Signal Transduction, Signaling Pathway, Vascular Inflammation

Immunogen affinity purified.

Liquid

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity) . .

1. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry. 1996 Mar 19; 35 (11) :3362-7. 2. Rottman JB, Ganley KP, Williams K, Wu L, Mackay CR, Ringler DJ. Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection. Am J Pathol. 1997 Nov; 151 (5) :1341-51. 3. Mummidi S, Ahuja SS, McDaniel BL, Ahuja SK. The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5'-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J Biol Chem. 1997 Dec 5; 272 (49) :30662-71.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

40785 MW

No cross reactivity with other proteins.

6

C-C chemokine receptor type 5

Cell membrane; Multi-pass membrane protein.

C-C chemokine receptor type 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.