Anti-C20orf74/RALGAPA2 Antilichaam Picoband® fluoro594 Vervoeging

Predicted to enable GTPase activator activity and protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. Located in cytosol and plasma membrane.

E3 ubiquitin-protein ligase RNF169; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169; RNF169; KIAA1991

RALGAPA2

57186

Q2PPJ7

Human

No cross-reactivity with other proteins.

E.coli-derived human C20orf74/RALGAPA2 recombinant protein (Position: R246-Q1556) .

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Flow Cytometry

Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage

Immunogen affinity purified.

Liquid

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.

1. Gridley, S., Chavez, J. A., Lane, W. S., Lienhard, G. E. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. Cell. Signal. 18: 1626-1632, 2006. 2. Gross, M. B. Personal Communication. Baltimore, Md. 4/6/2020. 3. Saito, R., Shirakawa, R., Nishiyama, H., Kobayashi, T., Kawato, M., Kanno, T., Nishizawa, K., Matsui, Y., Ohbayashi, T., Horiguchi, M., Nakamura, T., Ikeda, T., Yamane, K., Nakayama, E., Nakamura, E., Toda, Y., Kimura, T., Kita, T., Ogawa, O., Horiuchi, H. Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene 32: 894-902, 2013.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

41409 MW

6

Ring finger protein 169

Nucleoplasm.

Protein NDRG3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.