Anti-C7orf47/PPP1R35 Antibody Picoband® 31.0647 Vervoeging

PPP1R35 is a putative regulator of protein phosphatase-1. PPP1R35 is a centrosomal protein that regulates centriole elongation and centriole-to-centrosome conversion. Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity.

Transmembrane protein 240; TMEM240; C1orf70

PPP1R35

221908

Q8TAP8

Human

No cross-reactivity with other proteins.

E.coli-derived human C7orf47/PPP1R35 recombinant protein (Position: E27-A253) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Fong, C. S., Ozaki, K., Tsou, M.-F. B. PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion. Molec. Biol. Cell 29: 2801-2808, 2018. 2. Gross, M. B. Personal Communication. Baltimore, Md. 7/1/2020. 3. Hendrickx, A., Beullens, M., Ceulemans, H., Abt, T. D., Van Eynde, A., Nicolaescu, E., Lesage, B., Bollen, M. Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem. Biol. 16: 365-371, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

19908 MW

6

Transmembrane protein 240

Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.