Anti-Cytokeratin 1/KRT1 Antibody Picoband® 31.0647 Vervoeging

Keratin 1 is a Type II intermediate filament (IFs) of the intracytoplasmatic cytoskeleton. The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Pituitary homeobox 2; ALL1-responsive protein ARP1; Homeobox protein PITX2; Paired-like homeodomain transcription factor 2; RIEG bicoid-related homeobox transcription factor; Solurshin; PITX2; ARP1, RGS, RIEG, RIEG1

KRT1

3848

P04264

Human

No cross-reactivity with other proteins.

E.coli-derived human Cytokeratin 1/KRT1 recombinant protein (Position: L215-Q431) .

Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins

Immunogen affinity purified.

Liquid

Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. IsoformPTX2Cis involved in left-right asymmetry the developing embryo (By similarity) .

1. Chipev, C. C., Korge, B. P., Markova, N., Bale, S. J., DiGiovanna, J. J., Compton, J. G., Steinert, P. M. A leucine-to-proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis. Cell 70: 821-828, 1992. 2. Compton, J. G. Epidermal disease: faulty keratin filaments take their toll. Nature Genet. 6: 6-7, 1994. 3. Compton, J. G., DiGiovanna, J. J., Santucci, S. K., Kearns, K. S., Amos, C. I., Abangan, D. L., Korge, B. P., McBride, O. W., Steinert, P. M., Bale, S. J. Linkage of epidermolytic hyperkeratosis to the type II keratin gene cluster on chromosome 12q. Nature Genet. 1: 301-305, 1992.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

141435 MW

6

Pituitary homeobox 2

Secreted .

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.