Anti-Cytokeratin Peptide 18 KRT18 Antilichaam (monoclonaal, CY-90)

Intermediate filaments (IFs) are a structurally related family of cellular proteins that appear to be intimately involved with the cytoskeleton. Human keratin 18 (KRT18) and the homologous mouse Endo B are type I IF protein subunits whose expression is restricted in adults to a variety of simple epithelial tissues. The KRT18 gene is 3,791 bp long and the keratin 18 protein is coded for by 7 exons. The K18 gene is 3791 bp in length and the K18 protein is coded for by seven exons. By Southern blotting using the genomic DNA PCR product, the gene for keratin 18 is assigned to chromosome 12. Mutation of human keratin 18 in association with cryptogenic cirrhosis.

Boster Bio Anti-Cytokeratin Peptide 18 KRT18 Antibody (Monoclonal, CY-90) catalog # MA1026. Tested in IF, IHC, WB applications. This antibody reacts with Human.

Keratin, type I cytoskeletal 18; Cytokeratin-18; CK-18; Keratin-18; K18; Krt18 ; Krt1-18

KRT18

Human (3875), Mouse (16668), Rat (294853)

Q5BJY9

Human

No cross-reactivity with other proteins

The human epidermal carcinoma A-431 and MCF-7 human breast cancer cell lines.

Clone: CY-90

Expressed on the plasma membrane of hepatocytes and in the narrow apical portions of supporting cells in the vomeronasal sensory epithelium. Detected in the type III alveolar cells of the lung, in the proliferative crypt epithelium of the small intestine and in the older intragemmal cells of the tongue. .

IF, IHC, WB

Cell Type Markers, Class I, Cytoskeleton, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Intermediate Filaments, Microtubules, Signal Transduction, Structures, Tumor Associated

Ascites

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Lyophilized

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6) -mediated barrier protection (By similarity) . Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. .

1. Ku, N.-O.; Wright, T. L.; Terrault, N. A.; Gish, R.; Omary, M. B. : Mutation of human keratin 18 in association with cryptogenic cirrhosis. J. Clin. Invest. 99: 19-23, 1997. 2. Waseem, A.; Gough, A. C.; Spurr, N. K.; Lane, E. B. : Localization of the gene for human simple epithelial keratin 18 to chromosome 12 using polymerase chain reaction. Genomics 7: 188-194, 1990.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=MA1026

47761 MW

48 kDa

No cross reactivity with other proteins.

Keratin, type I cytoskeletal 18

Nucleus matrix . Nucleus, nucleolus . Cytoplasm .

Belongs to the intermediate filament family.

Keratin, type I cytoskeletal 18

Mouse IgG1

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.