Anti-DEPDC6/DEPTOR Antilichaam Picoband® 31.0550 Vervoeging

DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by the DEPTOR gene. Enables phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Is active in lysosomal membrane.

DEPTOR; DEPDC6; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6

DEPTOR

64798

Q8TB45

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human DEPDC6/DEPTOR recombinant protein (Position: A22-C409) . Human DEPDC6/DEPTOR shares 97.9% amino acid (aa) sequence identity with mouse DEPDC6/DEPTOR.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Hartz, P. A. Personal Communication. Baltimore, Md. 8/20/2009. 2. Peterson, T. R., Laplante, M., Thoreen, C. C., Sancak, Y., Kang, S. A., Kuehl, W. M., Gray, N. S., Sabatini, D. M. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137: 873-886, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

46 kDa

6

DEP domain containing MTOR interacting protein

DEP domain-containing mTOR-interacting protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.