Anti-DISC1 Antilichaam

Disrupted in schizophrenia 1 (DISC1) is a multifunctional scaffold protein that has important roles in neurodevelopment. DISC1 is expressed in both neuronal progenitor cells and postmitotic neurons in the developing cerebral cortex. DISC1 can interact with both centrosomal proteins and dynein-motor related proteins. In addition, DISC1 interacts with and inhibits the kinase GSK-3β to enable Wnt activation of β-catenin–mediated gene transcription and neuron proliferation. These functions of DISC1 may be regulated by post-translational modification. PKA and CDK5 can phosphorylate Ser-710, and a non-phosphorylatable Ser-710 mutant shows decreased interaction with the centrosomal proteins, BBS1 and BBS4, while a constituitively phosphorylated Ser-710 mutant shows increased interaction with these proteins. During neuronal progenitor cell proliferation, DISC1 phosphorylation at Ser-710 is low and the interaction with GSK-3β is enhanced. By contrast, DISC1 phosphorylation is increased, association with GSK-3β is decreased, and interaction with BBS1 is enhanced during postmitotic neuron migration.

Our DISC1 (C-terminus) rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects rat, mouse DISC1 (C-terminus) and is antigen affinity purified. It is great for use in ELISA, WB.

Our DISC1 (C-terminus) rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects rat, mouse DISC1 (C-terminus) and is antigen affinity purified. It is great for use in WB.

Disrupted schizophrenia

DISC1

Q811T9

Rat, Mouse

DISC1 synthetic peptide (coupled to KLH) containing amino acid residues from the C-terminus of mouse DISC1. This peptide sequence is well conserved in rat DISC1, but has 7 amino acid differences with the conserved site in human DISC1.

DISC1 (C-terminus)

Unconjugated

ELISA, WB

Neurodegenerative Disease, Alzheimer's Disease, Neurogenesis and Development

Antigen Affinity Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

100

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Affinity purified rabbit serum

1:1000

The antibody detects a 100 kDa* protein corresponding to the molecular mass of DISC1 on SDS-PAGE immunoblots of mouse brain and rat PC12 cells.

Western blots performed on each lot.

Rabbit

Liquid

IgG

Mouse

Quality Control: WB

AB_3068413