Anti-Dopamine Transporter/SLC6A3 Antibody Picoband® fluoro488 Vervoeging

This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.

Nitric oxide synthase, inducible;1.14.13.39; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; N

SLC6A3

6531

Q01959

Human

No cross-reactivity with other proteins.

E.coli-derived human Dopamine Transporter/SLC6A3 recombinant protein (Position: M1-V620) .

Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

Flow Cytometry

Cancer, Cancer Metabolism, Metabolism, Metabolism Processes, Neuroscience, Neurotransmission, Pathways and Processes, Response To Hypoxia

Immunogen affinity purified.

Liquid

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. As component of the iNOS- S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys- 247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. .

1. Brookes, K.-J., Mill, J., Guindalini, C., Curran, S., Xu, X., Knight, J., Chen, C.-K., Huang, Y.-S., Sethna, V., Taylor, E., Chen, W., Breen, G., Asherson, P. A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch. Gen. Psychiat. 63: 74-81, 2006. 2. Byerley, W., Hoff, M., Holik, J., Caron, M. G., Giros, B. VNTR polymorphism for the human dopamine transporter gene (DAT1) . Hum. Molec. Genet. 2: 335, 1993. 3. Cheuk, D. K. L., Li, S. Y. H., Wong, V. No association between VNTR polymorphisms of dopamine transporter gene and attention deficit hyperactivity disorder in Chinese children. Am. J. Med. Genet. 141B: 123-125, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

131117 MW

6

Nitric oxide synthase, inducible

Nucleus.

Nitric oxide synthase, inducible

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.