Anti-epidermale groeifactor EGF Antilichaam Picoband® fluoro550 Vervoeging

Epidermal growth factor (EGF) is a growth factor that plays an important role in the regulation of cell growth, proliferation and differentiation by binding to its receptor EGFR. EGF locus is mapped to 4q21-4qter. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bones. EGF results in cellular proliferation, differentiation, and survival while plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity.

Pro-epidermal growth factor; EGF; Epidermal growth factor; Egf

EGF

13645

P01132

Mouse

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of mouse EGF.

Expressed on activated B-cells.

Flow Cytometry

Cancer, Cell Biology, Cell Cycle, Cell Differentiation, Growth Factors, Growth Factors/Hormones, Signal Transduction

Immunogen affinity purified.

Liquid

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity) . .

1. Brissenden, J. E., Ullrich, A., Francke, U.Chromosomal mapping of loci for insulin-like growth factors I and II and for epidermal growth factor in man.Am. J. Hum. Genet.36: 133S-only, 1984. 2. Carpenter G, Cohen S (May 1990) . Epidermal growth factor. The Journal of Biological Chemistry 265 (14) : 7709–12. 3. Herbst RS (2004) . Review of epidermal growth factor receptor biology. International Journal of Radiation Oncology, Biology, Physics 59 (2 Suppl) : 21–6.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

133072 MW

No cross reactivity with other proteins.

6

Pro-epidermal growth factor

Membrane; Single-pass type I membrane protein.

Contains 9 EGF-like domains.

Pro-epidermal growth factor (EGF)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.