Anti-FENS1/WDFY1 Antibody Picoband® fluoro550 Vervoeging

The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain.

Pre T-cell antigen receptor alpha; pT-alpha; pTa; pT-alpha-TCR; PTCRA

WDFY1

57590

Q8IWB7

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human FENS1/WDFY1 recombinant protein (Position: H65-D394) .

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Flow Cytometry

Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage

Immunogen affinity purified.

Liquid

The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. .

1. Dutta, S., Roy, S., Polavaram, N. S., Baretton, G. B., Muders, M. H., Batra, S., Datta, K. NRP2 transcriptionally regulates its downstream effector WDFY1. Sci. Rep. 6: 23588, 2016. Note: Electronic Article. 2. Gross, M. B. Personal Communication. Baltimore, Md. 8/8/2018. 3. Hu, Y.-H., Zhang, Y., Jiang, L.-Q., Wang, S., Lei, C.-Q., Sun, M.-S., Shu, H.-B., Liu, Y. WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO Rep. 16: 447-455, 2015.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

41409 MW

6

Pre T cell antigen receptor alpha

Membrane; Single-pass type I membrane protein.

Protein NDRG3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.